Gholamreza Azizi Selected Research

guluronic acid

4/2020	The Effects of G2013 (α-L-guluronic Acid) in a Pentylenetetrazole-induced Kindling Animal Model of Epilepsy.
2/2020	Effects of guluronic acid, as a new NSAID with immunomodulatory properties on IL-17, RORγt, IL-4 and GATA-3 gene expression in rheumatoid arthritis patients.
1/2020	Pivotal cytokines and their transcription factors are the targets of guluronic acid (G2013) for inhibiting the immunopathogenesis process of multiple sclerosis.
1/2019	Antagonistic Property of G2013 (α-L-Guluronic Acid) on Gene Expression of MyD88, Tollip, and NF-κB in HEK293 TLR2 and HEK293 TLR4.
1/2016	Anti-aging property of G2013 molecule as a novel immunosuppressive agent on enzymatic and non-enzymatic oxidative stress determinants in Rat model.
9/2015	New therapeutic approach by G2013 in experimental model of multiple sclerosis.

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Gholamreza Azizi Research Topics

Disease

22	Neoplasms (Cancer) 01/2022 - 10/2018
15	Multiple Sclerosis 01/2022 - 04/2013
13	Primary Immunodeficiency Diseases 04/2022 - 01/2016
11	Inflammation (Inflammations) 04/2022 - 12/2012
10	Infections 05/2022 - 02/2017
9	Rheumatoid Arthritis 01/2022 - 03/2013
7	Agammaglobulinemia (Hypogammaglobulinemia) 05/2022 - 01/2016
7	Common Variable Immunodeficiency 02/2022 - 01/2016
7	Breast Neoplasms (Breast Cancer) 04/2020 - 10/2018
6	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 09/2013
6	Reinfection 01/2022 - 01/2016
6	Neoplasm Metastasis (Metastasis) 10/2020 - 12/2018
5	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2021 - 04/2013
5	Ankylosing Spondylitis 01/2020 - 06/2015
4	Disease Progression 01/2021 - 12/2012
3	Respiratory Tract Infections (Respiratory Tract Infection) 04/2022 - 01/2019
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 01/2019
3	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2022 - 01/2018
3	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2022 - 06/2015
3	Demyelinating Diseases (Demyelinating Disease) 01/2021 - 02/2014
3	Bacterial Infections (Bacterial Infection) 01/2020 - 10/2017
2	IgA Deficiency 05/2022 - 01/2017
2	COVID-19 05/2022 - 04/2021
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2022 - 09/2013
2	Autoimmune Lymphoproliferative Syndrome 04/2022 - 02/2022
2	Hypersensitivity (Allergy) 01/2022 - 06/2017
2	Eosinophilia 01/2022 - 01/2020
2	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2022 - 08/2015
2	Epilepsy (Aura) 01/2021 - 04/2020
2	Hypoxia (Hypoxemia) 05/2020 - 10/2018
2	Carcinogenesis 10/2019 - 01/2019
2	Poliomyelitis (Polio) 01/2018 - 01/2018
2	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 09/2016 - 01/2015
2	Alzheimer Disease (Alzheimer's Disease) 08/2014 - 12/2012
2	Pain (Aches) 03/2014 - 03/2013
2	Edema (Dropsy) 03/2014 - 03/2013
1	Communicable Diseases (Infectious Diseases) 05/2022
1	Autoimmune Polyendocrinopathies (Schmidt Syndrome) 05/2022
1	Autoimmune Thyroiditis (Lymphomatous Thyroiditis) 05/2022
1	Diabetes Mellitus 05/2022
1	Protein Deficiency 04/2022
1	Lymphoma (Lymphomas) 04/2022
1	Hyper-IgM Immunodeficiency Syndrome (Hyper-IgM Syndrome) 04/2022
1	Epstein-Barr Virus Infections 02/2022

Drug/Important Bio-Agent (IBA)

15	CytokinesIBA 01/2022 - 12/2012
12	Immunoglobulins (Immunoglobulin)IBA 04/2022 - 01/2017
10	Immunoglobulin M (IgM)IBA 12/2021 - 10/2017
9	Immunoglobulin A (IgA)IBA 05/2022 - 03/2016
9	Proteins (Proteins, Gene)FDA Link 02/2022 - 06/2017
6	Interleukin-6 (Interleukin 6)IBA 01/2021 - 10/2018
6	VaccinesIBA 10/2020 - 01/2018
6	guluronic acidIBA 04/2020 - 09/2015
5	Immunoglobulin E (IgE)IBA 01/2022 - 06/2017
5	Interleukin-22 (IL-22)IBA 05/2021 - 01/2015
5	Immunoglobulin G (IgG)IBA 01/2021 - 01/2019
5	Small Interfering RNA (siRNA)IBA 10/2020 - 10/2018
5	EnzymesIBA 11/2019 - 03/2013
4	MicroRNAs (MicroRNA)IBA 01/2021 - 01/2018
4	Therapeutic UsesIBA 01/2018 - 06/2015
3	LipopolysaccharidesIBA 04/2022 - 01/2019
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2022 - 10/2016
3	AntibodiesIBA 01/2022 - 01/2016
3	InterleukinsIBA 01/2021 - 04/2014
3	Pharmaceutical PreparationsIBA 10/2020 - 09/2013
3	chitosan lactateIBA 10/2020 - 10/2018
3	Transcription Factors (Transcription Factor)IBA 05/2020 - 05/2014
3	Adenosine (Adenocard)FDA LinkGeneric 07/2019 - 10/2018
2	Interleukin-10 (Interleukin 10)IBA 01/2022 - 01/2019
2	AntigensIBA 01/2022 - 01/2019
2	Interleukin-17 (Interleukin 17)IBA 01/2022 - 02/2020
2	Antiviral Agents (Antivirals)IBA 04/2021 - 01/2018
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 05/2020
2	Immune Checkpoint ProteinsIBA 10/2020 - 04/2020
2	Peptides (Polypeptides)IBA 09/2020 - 10/2018
2	ChitosanIBA 09/2020 - 05/2020
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2020 - 10/2018
2	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 05/2020 - 07/2019
2	AntioxidantsIBA 04/2020 - 01/2014
2	Interleukin-4 (Interleukin 4)IBA 02/2020 - 04/2014
2	ChemokinesIBA 02/2020 - 08/2014
2	AminopeptidasesIBA 01/2020 - 10/2018
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 10/2019 - 10/2018
2	D-Aspartic Acid (D Aspartate)IBA 01/2019 - 07/2017
2	Agammaglobulinaemia Tyrosine KinaseIBA 01/2019 - 01/2019
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2019 - 01/2016
2	CD40 Ligand (CD40L)IBA 01/2019 - 01/2019
2	Oral Poliovirus Vaccine (Sabin Vaccine)IBA 01/2018 - 01/2018
2	Inosine Triphosphate (ITP)IBA 09/2016 - 01/2015
2	AutoantigensIBA 01/2015 - 08/2013
2	Tyrosine Kinase InhibitorsIBA 07/2014 - 09/2013
2	Imatinib Mesylate (Gleevec)FDA Link 06/2014 - 09/2013
2	LeukotrienesIBA 03/2014 - 03/2013
2	LipidsIBA 03/2014 - 03/2013
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 05/2022
1	EndocannabinoidsIBA 05/2022
1	Phosphatidylinositols (Phosphatidylinositol)IBA 04/2022
1	Protein Kinase C-deltaIBA 02/2022

Therapy/Procedure

16	Therapeutics 06/2021 - 09/2013
6	Immunotherapy 04/2021 - 06/2017
2	Hematopoietic Stem Cell Transplantation 01/2022 - 01/2018